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Published Research on Low Intensity Therapeutic Ultrasound (LITUS™)

Low intensity ultrasound therapy was originally developed as a bone fracture repair therapy for non-union fractures. Scientists and clinicians found that longer duration, low intensity therapy helped to increase the natural healing rate of the body. LITUS therapies later expanded into soft tissue healing applications like tendon and ligament healing.

Read a full summary compilation of low intensity ultrasound therapy in published research.
The published studies below are examples of research completed within the last decade showing the efficacy of LIUS treatments

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Tendon Healing

1. Yeung et al. "Pulsed Ultrasound Treatment Accelerates the Repair of Achilles Tendon Rupture in Rats, " Wiley Periodicals, Inc. J Orthop Res 24:193–201, 2006
"Findings suggested that Pulsed Ultrasound was able to accelerate the healing of the ruptured tendons. Results showed more regular, denser, and better aligned collagen fibers in the healing scar of the PUS-treated healing tendons."

2. Papatheodorou et al. "Effect Of Transosseous Application Of Low-Intensity Ultrasound At The Tendon Graft-Bone Interface Healing," Ultrasound in Med. & Biol., Vol. 35, No. 4, pp. 576–584, 2009 "Findings suggest that transosseous application of LiUS enhances the healing rate of the tendon graft-bone interface."

3. Read more in the larger research compilation.

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Arthritis

1. Min et al. "Effects of low-intensity ultrasound (LIUS) stimulation on human cartilage explants," Scand J Rheumatol 2006;35:305–311 "LIUS has anabolic effects on human cartilage in explant cultures, indicating a potentially important method for the repair of osteoarthritic cartilage."

2. Naito et al. "Low-Intensity Pulsed Ultrasound (LIPUS) Increases the Articular Cartilage Type II Collagen in a Rat Osteoarthritis Model," Wiley Periodicals, Inc. J Orthop Res 28:361–369, 2010 "LIPUS is likely to increase the type II collagen synthesis in articular cartilage, possibly via the activation of chondrocytes and induction of type II collagen mRNA expression."

3. Read more in the larger research compilation.

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Fracture Healing

1. Claes et al. "The enhancement of bone regeneration by ultrasound," Progress in Biophysics and Molecular Biology 93 (2007) 384–398 "LIPUS treatment has led to increased callus area and accelerated return of bone strength following fracture. Histological studies suggest that LIPUS influences all major cell types involved in bone healing, including osteoblasts, osteoclasts, chondrocytes and mesenchymal stem cells."

2. Leung et al. "Low-Magnitude High-Frequency Vibration Accelerates Callus Formation, Mineralization, and Fracture Healing in Rats," Wiley Periodicals, Inc. J Orthop Res 27:458–465, 2009 "Results showed the acceleration of callus formation, mineralization, and fracture healing in the treatment group. It is concluded that LMHFV enhances healing in the closed femoral shaft fracture."

3. Read more in the larger research compilation.